Scientist l, Biologics LCMS Bioanalysis, QTAS

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

AbbVie Inc is embracing new paradigms and technologies to develop novel and life-changing therapies across a diverse range of therapeutic areas. The Quantitative, Translational ADME  Sciences (QTAS) department at AbbVie is seeking a highly motivated and energetic bioanalytical scientist to join the biologics bioanalysis, characterization and proteomics (BBCP) group. The main function of this position will be supporting LC-MS (liquid chromatography-mass spectrometry) - based bioanalysis and method development of biologics entities, specifically for multi-specific antibodies and antibody drug conjugates (ADCs) etc. The ideal candidate will be experienced in the 
optimization and implementation of LC-MS-based bioanalytical methods to support pre-clinical in vivo PK and TK studies. The candidate will be responsible for routine sample preparation, method  development, instrument maintenance, data analysis, writing reports, and presenting data at internal and external meetings.

Responsibilities:  

• Perform high-throughput quantitative bioanalysis of biologic therapeutics in biofluids and tissues for PK/PD and TK studies.
• Optimize and develop bioanalytical methods for quantifying multi-specific antibodies/drug conjugates in biological matrices using LC-MS MRM assays.
• Operate and maintain LCMS and automation instruments; handle troubleshooting as needed.
• Maintain electronic laboratory notebooks (ELN) and manage study documentation in the Laboratory Information Management System (LIMS).
• Collaborate with project representatives and bioanalytical scientists with different backgrounds (LCMS and LBA). Present work internally and externally.

• Degree in chemistry, pharmacology or other related fields. BS with 5+ years or MS with 2+ years in a pharmaceutical industry setting with a focus on bioanalysis and mass spectrometry.
• Motivated with a strong technical background in high-throughput LC-MS assay operations. 
• Highly organized and attention to detail.
• Direct experience with multi-specific antibodies and ADCs, including bioanalysis in biological matrices and method development for evaluating in vivo stability is a must.
• Experience with immune-affinity purification and sample preparation using automation systems (e.g., TECAN, AssayMap Bravo) is required.
• Broad knowledge in analytical separation science and hands-on experience with Agilent 
• UPLC and SCIEX Triple Quad mass spectrometer is required. Experience with high resolution mass spectrometers (TOF or orbitrap) is a plus.
• Proficiency in managing LIMS software for sample, data, and workflow management is preferred.
• Strong data analytical skills: familiarity with Skyline, Analyst, and SCIEX OS for data processing is preferred.
• Excellent verbal and written communication skills, strong organizational abilities, and the ability to work independently and thrive in a matrix team environment.
• Desire to excel in a fast-paced environment, with strong problem-solving skills, and the ability to prioritize tasks and meet deadlines effectively.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​​

  
  

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​​

  
  

• This job is eligible to participate in our short-term incentive programs. ​​

  
  

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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