Manager, Cell sorting and Antibody development

Work Schedule

Environmental Conditions

Job Description

About the company

Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $44 billion. Our Mission is to enable our customers to make the world healthier, cleaner, and safer. Whether our customers are accelerating life sciences research, solving analytical challenges, growing efficiency in their laboratories, improving patient health through diagnostics, or developing and manufacturing life-changing therapies, we are here to support them. Our distributed team delivers an outstanding combination of innovative technologies, purchasing convenience, and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon, and PPD. Our Innovative Laboratory technologies & Services makes it easier for customers.

About Team: Antibody team

The antibody team is involved in development and engineering of antibodies, with a deep focus on reagent quality and specificity. The core activities of team include design, development, purification, conjugation and testing of antibodies in a variety of immunoassay applications using current tools and technologies. The goal of the program is sophisticated product development and creation of product specific information to promote research use.

Role & Responsibilities

Role:

To be an integral part of an antibody development team with a focus on performance and specificity using innovative molecular, protein, and cell biology methods. The successful candidate will be joining Bangalore R&D leadership team in developing products and solutions for developing, validating and characterizing antibodies for the Thermo Fisher Scientific Antibody portfolio. The candidate should be well versed with Antibody development using state-of-art cell, molecular and recombinant methods for creating data sets to enable high quality products to customers. This position involves people management, internal, external and cross function teamwork to drive technical strategies for execution in R&D projects involving state-of-art methods.

Responsibilities:

• Contribute in a fast- paced environment towards Antibody development & Validation
• R&D Manager role in new Antibody development projects using single B cell sorting, with vast experience in experimental planning and execution to meet the program schedule
• Develop a team of scientists in matrix style operation, provide technical and operational supervision.
• Good scientific writing skills, establishing technical protocols for effective transfer to operation teams.
• Mentoring and training junior scientists in research, designing and experimental execution, interpreting data and data presentation to the stakeholders
• Good documentation practice is a must to maintain data integrity and accuracy.
• Delivering high quality results according to project schedule in support of product commercialization from concept to launch including early feasibility, development and validation phases.
• Support the manufacturing team for technical support and quality by providing technical guidance.

Candidate Requirement:

Education & Experience levels:

Applicants should have a Ph.D in Biotechnology/Life Sciences or related subject area with over 10 years proven experience. Minimum 3-4 years of Industrial experience is required.

Nature of experience:

• Experience with antibody development and engineering including hybridoma, single B cell, and other recombinant antibody platforms
• Deep understanding of antibody development using single B cell sorting methodology
• Knowledge of B cell biology and the science of antibody development is an advantage
• Experience in applying scientific principles and concepts in antibody development platforms with knowledge of emerging technologies such as deep sequencing or mining of antibody repertoires using NGS (next generation sequencing), phage or cell display, affinity maturation etc. Spatial omics knowledge is a plus.
• Prior work in single cell molecular biology workflows, next generation sequencing and/or display technologies desirable.
• Strong background in flow cytometry including single cell sorting, immunophenotyping, multicolor flow cytometry and panel design, rare population analysis
• Proficiency in high-throughput molecular cloning methods
• Thorough in biochemical and immunoassay workflows such as recombinant protein expression and purification, ELISA, SDS-PAGE, Western blotting, IF, IHC
• Working knowledge of fluorescence microscopy, fluorescence detection technologies is helpful
• Broad knowledge and experience in molecular biology, protein design, engineering, purification, and conjugation
• Ability to provide technical trouble shooting to resolve scientific problems.
• Authorship of peer-reviewed publications with post-doctoral experience and a strong, independent understanding of standard and emerging research protocols and techniques are preferred. GLP experience is a must.
• Experience in authoring and optimizing standard operating procedures with a focus on reproducibility
• Skills for identifying deviations from expected outcomes, problem solving and suggesting alternatives
• Excellent written and verbal presentation skills
• Proven leadership skills and ability to work alongside colleagues from different backgrounds
• Prior project and people leadership experience preferred.

The successful candidate will be self-motivated and a self-starter who is excellent at learning and applying new concepts for process or product improvements, possess excellent oral and written communication skills to connect to peers and leadership, and will be an excellent teammate with the ability to work with diverse colleagues.

Thermo Fisher Scientific is an equal opportunity employer and value diversity at our company. All qualified applicants will receive consideration for employment without discrimination basis race, color, religion, sex, sexual orientation, gender, gender identity or expression, national origin, protected veteran status, age, genetics, pregnancy, disability or any other legally protected status. Thermo Fisher Scientific aligns with all applicable equal employment opportunity legislation in each jurisdiction in which it operates.

We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation!

ThermoFisher is committed to crafting a diverse work environment that values and respects individuals from all backgrounds. Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.