AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.
Organization Description
The Molecular Profiling and Drug Delivery (MPDD) function within the Small Molecule CMC organization is accountable for a broad range of deliverables across various stages of drug discovery and development. During lead optimization and through candidate selection, MPDD scientists utilize state of the art automation and computational tools supported by expertise in biopharmaceutics, drug delivery, and solid-state chemistry to collaboratively progress candidates with higher probability of success into development and advise clinical formulation strategy. From candidate selection through clinical proof of concept and product launch, MPDD scientists work in cross functional teams to identify the commercial solid form of the active pharmaceutical ingredient (API) and establish structure-property-performance correlations to help deliver robust commercial processes and align control strategies across drug substance and product. They also transition drug substance isolation processes and relevant physical characterization methods to commercial manufacturing sites and work within teams to ensure successful regulatory submissions.
Scientists within AbbVie's MPDD organization work collaboratively with other functions within Development Sciences and Discovery to conduct developability assessment to select molecules with higher probability of success for clinical development and eventual commercialization. This includes profiling of physicochemical properties, development of preclinical formulations, identifying solutions to in vivo absorption challenges, and advancement of novel drug delivery strategies across multiple routes of administration that are aligned with program target product profiles and downstream partners. Modalities of interest include traditional small molecules as well as complex chemically synthesized modalities such as PROTACs and are administered as immediate oral formulations as well as subcutaneous or intramuscular sustained release drug depot delivery systems. In this role, you will work in cross-functional teams in matrixed environments and engage in multidisciplinary problem solving.
Responsibilities
AbbVie's MPDD organization is seeking a highly motivated, talented, and creative scientist with expertise and some experience in pharmaceutical sciences and drug delivery for a Senior Scientist II position. The primary role of this position is to serve as an MPDD project leader on discovery programs, leading CMC developability assessment for emerging molecules on small molecule pipeline programs. Within the projects, small molecules are delivered across different routes of administration, e.g. oral delivery as well as parenteral delivery by injecting subcutaneous or intramuscular depot formulations. This role will also entail contributing towards developing our drug delivery capabilities with a focus on complex chemically synthesized modalities such as PROTACS. This person will be working collaboratively with discovery and development partners across disciplines to advance molecules to clinical development with improved developability profiles. The candidate will be a MPDD project leader within dynamic, engaging, and multidisciplinary project teams with the ability to apply their expertise and leadership skills to advise teams on key developability risks and the prioritization of mitigation strategies. Formulation design of immediate release oral formulations and parenteral drug depot formulations will be a focus for this position.
The desired candidate will have a strong background and hand-on experience in the areas of physicochemical and/or biophysical properties and their impact on developability, preclinical and/or clinical formulation, biopharmaceutics relevant to small molecules across different routes of administration. Specifically, the candidate should have experience developing immediate release oral drug formulations applying enabling manufacturing technologies for poorly soluble drugs (e.g. amorphous solid dispersions) as well as for formulating subcutaneous or intramuscular depot delivery systems (Long-Acting Injectables) for sustained delivery concepts.
Key Competencies
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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