Principal Research Scientist I, siRNA Therapeutics

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

We are seeking a highly motivated and collaborative scientist with a background in neuroscience to join the siRNA therapeutics team at AbbVie. The candidate will be part of the newly formed siRNA team to build an internal siRNA platform for translational research to develop transformational therapeutics for immunology, neuroscience and oncology. The successful candidate will be part of a growing therapeutic siRNA group working with cross-disciplinary teams internally and externally. The candidate will serve as a lead scientist on their own project and contribute scientific insights into multiple other projects.

Responsibilities:

• Function as a principal investigator to advance internal siRNA technology and programs related to neuroscience indications
• Independently responsible for project science within their area of expertise on one or more project teams
• Collaborate with therapeutic area colleagues to advance siRNA technology applied to internal programs
• Direct research and mentor a group of scientists within area of expertise
• Optimize internal siRNA platforms for functional tissue specific delivery
• Manage external CROs and internal resources to meet budget and timeline constraints
• Collaborate closely with internal colleagues to advance cross-functional collaborative experiments and projects
• Serve as a subject matter expert for siRNA delivery to target tissues and experimental design & execution
• Anticipate and critically evaluate scientific advanced or competitive threats and respond with appropriate new strategies
• Generate new scientific proposals and lead those efforts
• Clearly communicate technology achievements and needs with management and cross functional collaborators

Qualifications:

• BS with typically 14+ years, MS with typically 12+ years, or PhD with typically 6+ years of related work experience in biotech or pharma
• Previous experience with siRNA antibody conjugates and downstream assays to measure efficacy
• Experience with antisense oligonucleotides (ASOs)
• Deep experience in cell culture techniques and downstream assays to evaluate RNAi compounds
• Previous experience in animal study design and downstream assays to evaluate genetic medicines
• Experience with extrahepatic delivery of therapeutic siRNA is a plus
• Well versed with previous experience in the field of neuroscience
• Excellent communication and interpersonal skills. Listens and understands others’ point of view and articulates own perspective tacitly in order to clearly communicate scientific findings with key stakeholders

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.​

  
  

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.​

  
  

• This job is eligible to participate in our short-term incentive programs. ​

  
  

• This job is eligible to participate in our long-term incentive programs​

  
  

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ​

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion.  It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.

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